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Ledipasvir/Sofosbuvir Tablet

药品名称:Ledipasvir/Sofosbuvir Tablet

剂型规格:片剂 Ledipasvir(LDV) 90mg 、Sofosbuvir(SOF)400mg

适应症:用于基因型1慢性丙型肝炎成人感染者的治疗

注册类别:化3+6类

产品信息:

据估计,世界范围内大约有1. 7 亿人感染丙型肝炎病毒( HCV) ,占世界总人口的3%。这些感染了HCV 的患者中, 80%会发展成慢性丙肝。慢性丙肝患者中,又有20% 的患者会发展成肝硬化,有25%的可能发展成肝癌。

吉利德(Gilead)2月10日宣布,已向FDA提交了ledipasvir(LDV)+sofosbuvir(SOF)固定剂量组合片剂(LDV/SOF,90mg/400mg)新药申请(NDA),该药开发用于基因型1慢性丙型肝炎成人感染者的治疗。据估计,在美国约75%的丙肝患者为基因型1 HCV毒株感染。
2013年7月25日,FDA已授予LDV/SOF固定剂量组合药物突破性疗法认定。LDV/SOF NDA的提交,是基于3项III期研究(ION-1、ION-2、ION-3)的数据。

吉利德研发执行副总裁兼首席科学官Norbert Bischofberger博士称:“LDV/SOF NDA的提交,使我们离为所有丙型肝炎患者提供一种简单、安全、高效全口服治疗方案的目标更近了一步。根据III期研究的数据,LDV/SOF组合疗法有望在短至8周的时间里治愈基因型1 HCV患者,同时无需注射干扰素或联合利巴韦林(ribavirin)。该复方制剂预计2014年底获FDA批准上市。

Ledipasvir介绍:

代号:GS-5885

化学结构式:



化学名称(英文):MethylN-[(2S)-1-[(6S)-6-[5-[9,9-Difluoro-7-[2-[(1S,2S,4R)-3-[(2S)-2-(methoxyca... Read more »
Views: 76 | Added by: Weifeng | Date: 11.02.2016 | Comments (0)

目前已有超过百人随康安途孟加拉国用吉二代(Lesovir-C、Twinvir)治疗丙肝,疗效非常好,目前所有检测的患者检测结果都已经转阴。 联系 Dr. Md. Kais Haider Chowdhury医生(顾问) Dhaka Medical College & Hospital (达卡医学院) Medicine Unit (内科区) Mobile: 00 88 01971951824 (手机号码) Consult Now在线顾问
Views: 74 | Added by: Weifeng | Date: 07.02.2016 | Comments (0)

招 聘 NEWAYSINTERNATIONAL COMPANY LIMITED NEWAYSINTERNATIONAL COMPANY LIMITED(以下简称NEWAYS)是一家以港式点心为主营产品的连锁企业,并致力于港式点心在全球的推广和发展。我们秉承创新与合作的精神,合力打造一个开放分布式的动态平台型企业­(即:公司在职核心管理层将持有控股公司或其子公司一定数额的股权或期权) 基本待遇: 1、包食宿及签证费用 2、工作满一年提供4000元的机票补贴 3、工资及其它待遇面谈 工作地点:孟加拉达卡市 ★★应聘行政岗位的人才需具备以下基本条件: 1、英语沟通能力强,熟悉电脑和办公软件的操作 2、为人诚恳,品行端正,可塑性强,能够承受工作压力 3、精通孟加拉文说写者优先录用,并作为公司孟加拉区高层主管的重点培养对象。 一、行政文员 多名 要求:1、有行政工作者优先 2、应届毕业生亦可 二、总经理助理 1名 应届毕业生亦可 三、经理助理多名 应届毕业生亦可 四、储备干部 多名 应届毕业生亦可 ★★应聘生产岗位的人才需具备以下基本条件:为人诚恳,品行端正,责任心强,能够承受工作压力 一、点心师傅 1名要求:必须有做港式点心的丰富经验 二、食品车间生产主管2名要求:有3年以上速冻食品相关加工企业的管理或研发经验. 地址:G3,Garden Road19/2(Gulmohor), Kawran Bazar,Dhaka,Bangladesh 联系电话:+88 01688189796 +8801624992229 联系QQ:572238960 邮箱:neways_hr@hotmail.com 微信:thunder0663或jackyliang2011
Views: 238 | Added by: Weifeng | Date: 04.05.2015 | Comments (0)

Job in Chinese University

Medical Teacher

Post: Lecturer
Teaching Subject: Human Anatomy (Systemic and Regional Anatomy)
Qualifications: MBBS (post graduation preferred)
Experience: Medical Teacher or Hospital Job

Call: 00 88 01534668314
Email: xue.edu.ms@asia.com
Views: 242 | Added by: Weifeng | Date: 05.04.2015 | Comments (0)

Goal-Directed Fluid Management Based on The Pulse Oximeter-Derived Pleth Variability Index

目标指导液体管理基于脉搏血氧计派生 脉搏灌注变异指数(PVI)

Reduces Lactate Levels and Improves Fluid Management.
Methods

降低乳酸水平、提高液体管理。

Methods
方法

Eighty-two patients scheduled for major abdominal surgery were randomized into 2 groups to compare
intraoperative PVI-directed fluid management (PVI group) versus standard care (control group)

定于82例腹部大手术患者随机分为2组术中PVI指示液体管理(PVI组)与标准治疗(对照组)进行比较。

After the induction of general anesthesia, the PVI group received a 500-mL crystalloid bolus and a crystalloid infusion of 2 mL • kg(-1) • h(-1).

全身麻醉诱导后,PVI组收到了500ml的晶体推注和 2ml/Kg/H 晶体液注输

Colloids of 250 mL were administered if the PVI was >13% Vasoactive drug support was given to maintain the mean arterial blood pressure above 65 mm Hg.

250mL的胶体给药, 如果PVI >13%的血管活性药物上给予支持,以维持平均动脉血压高于65mmHg <... Read more »
Views: 18967 | Added by: Weifeng | Date: 05.07.2013 | Comments (0)

Xinhua | 2013-3-31 9:05:34

Yemeni Prime Minister Mohammed Salem Basindwa on Saturday met here with a visiting delegation of China's health ministry, expressing hopes that medical and health cooperation between the two countries would be further strengthened.

During the meeting, Basindwa said China and Yemen had enjoyed five decades of medical and health cooperation, which showed China 's support to the Arab country.

The Chinese medical teams have been healing the wounded and saving lives across Yemen for 47 years, contributing to the improvement of the Yemeni people's livelihood, Basindwa said.

The Yemeni government welcomes the return of the Chinese medical personnel after they left the country due to the 2011 unrest and hopes that bilateral health cooperation will be strengthened in the future, he added.

Chinese ambassador to Yemen Chang Hua, for his part, said China sent its first medical team to Yemen in 1966 and since then, more than 3,400 doctors and nurses had been working in the country and made contribution to the Yemeni people's health improvement.
... Read more »
Views: 2395 | Added by: Weifeng | Date: 01.04.2013 | Comments (0)

March 28, 2013 in Diabetes (Medical Xpress)—Traditional Chinese medicine could be a key weapon in the treatment of type 2 diabetes, a joint international study has found. Researchers, including The University of Queensland's Dr Sanjoy Paul and Peking University's Professor Lilong Ji from Beijing, have found that conventional drugs were significantly more effective when used alongside traditional Chinese medicine in the treatment of type 2 diabetes. The study involved a controlled clinical trial of 800 type 2 diabetic adults, comparing anti-diabetic drug Glibenclamide as a stand-alone treatment and treatment with Glibenclamide in conjunction with traditional Chinese medicine. Dr Paul, who is Director of the Queensland Clinical Trials and Biostatistics Centre in UQ's School of Population Health, said results showed patients treated with traditional Chinese medicine were more than a third less likely to experience hypoglycaemia – dangerously low levels of blood sugar – than those treated... Read more »
Views: 2320 | Added by: Weifeng | Date: 01.04.2013 | Comments (0)

NAIROBI, Feb. 26 (Xinhua) -- Kenyan President Mwai Kibaki on Tuesday officially opened a hospital whose construction was funded by the Chinese government to scale up access to health services in the East African country.

Kibaki, who opened the Mama Lucy Kibaki Hospital, said the institution is a key development in the government's efforts to provide accessible health services to Kenyans.

"The Chinese government financed the construction of the hospital as well as provision of medical equipment. On its part, the government of Kenya provided the land on which the hospital is built and also financed construction of support works as well as purchase of additional equipment," he said.

The Kenyan leader noted that both the Kenya and Chinese governments contributed to the construction of the health facility, saying the development was a good example of partnerships between governments in efforts to improve the welfare of citizens.

He noted that the Mama Lucy Kibaki Hospital has served to decentralize and expand health services not only to patients in the Eastern part of Nairobi County but also has reduced the pressure on Kenyatta National Hospital which was previously serving the area residents.

Kibaki reaffirmed his government's commitment to improving both preventive and curative health services, saying over the last 10 years the government has sought to provide quality, affordable and accessible healthcare to all Kenyans.... Read more »
Views: 4799 | Added by: Weifeng | Date: 01.03.2013 | Comments (2)

Introduction
The scientists found that the EEG contains information on the activities of the neurotransmitter, which founded the of

"EEG fluctuation theory" when the neurotransmitter receptor role to produce electricity changes, and pass all electrical changes to the scalp and EEG was incorporated. In other words, the EEG contains information on the activities of the neurotransmitter. Fluctuation theory, analysis of brain activity provides a new perspective, the overall non-invasive analysis of the functional activity of neurotransmitters and brain possible. Encephalofluctuograph instrument (Encephalofluctuograph, EFG) fluctuation theory in the development of the EEG on the basis of a qualitative change in the EEG science; like CT is developed on the basis of the ordinary X-ray diagnostic techniques , but the X-ray diagnostic techniques in a qualitative change. EFG through the acquisition of EEG, the application of special methods of EEG signals were analyzed... Read more »
Views: 6684 | Added by: Weifeng | Date: 29.11.2012 | Comments (0)

20120906_retinalimage_photo_1.jpg20120906_retinalimage_photo_2.jpg20120906_retinalimage_photo_3.jpg















CUHK Develops an Automatic Retinal Image Analysis System to Help Diabetes Patients and Elderly Prevent Stroke


A ... Read more »
Views: 2004 | Added by: Weifeng | Date: 05.10.2012 | Comments (0)

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